Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists

J Med Chem. 1990 Jan;33(1):13-6. doi: 10.1021/jm00163a003.

Authors

A A Nagel¹, T Rosen, J Rizzi, J Daffeh, K Guarino, J Nowakowski, L A Vincent, J Heym, S McLean, T Seeger, et al.

Affiliation

¹ Department of Medicinal Chemistry, Pfizer Central Research, Groton, Connecticut 06340.

PMID: 2296012
DOI: 10.1021/jm00163a003

No abstract available

MeSH terms

Animals
Binding, Competitive
Heart Rate / drug effects
Molecular Structure
Rats
Receptors, Serotonin / metabolism
Serotonin Antagonists*
Structure-Activity Relationship
Thiazoles / metabolism
Thiazoles / pharmacology*
Tumor Cells, Cultured

Substances

Receptors, Serotonin
Serotonin Antagonists
Thiazoles